SCHEDULE 14A

                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                              EXCHANGE ACT OF 1934
                                (Amendment No. )

Filed by the registrant [X]

Filed by a party other than the registrant [ ]

Check the appropriate box:

[ ]   Preliminary proxy statement.

[ ]   Confidential, for use of the Commission only (as permitted by Rule
      14a-6(e)(2)).

[X]   Definitive proxy statement.

[ ]   Definitive additional materials.

[ ]   Soliciting material under Rule 14a-12Section 240.14a-12

                          Third Wave Technologies, Inc.
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                (Name of Registrant as Specified in Its Charter)

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      (Name of Person(s) Filing Proxy Statement if Other Than the Registrant)

Payment of filing fee (check the appropriate box):

[X]   No fee required.

[ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      (1)   Title of each class of securities to which transaction applies:

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      (2)   Aggregate number of securities to which transaction applies:

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      (3)   Per unit price or other underlying value of transaction computed
            pursuant to Exchange Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):

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      (4)   Proposed maximum aggregate value of transaction:

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      (5)   Total fee paid:

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      [ ]   Fee paid previously with preliminary materials.

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      [ ]   Check box if any part of the fee is offset as provided by Exchange
            Act Rule 0-11(a)(2) and identify the filing for which the offsetting
            fee was paid previously. Identify the previous filing by
            registration statement number, or the form or schedule and the date
            of its filing.

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      (1)   Amount Previously Paid:

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      (2)   Form, Schedule or Registration Statement No.:

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      (3)   Filing Party:

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      (4)   Date Filed:
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                         THIRD WAVE TECHNOLOGIES, INC.
                             ---------------------

                      20032005 ANNUAL MEETING OF SHAREHOLDERS
                            TO BE HELD JUNE 10, 200314, 2005
                             ---------------------

To our Shareholders:

     NOTICE IS HEREBY GIVEN that the annual meeting of shareholders of Third
Wave Technologies, Inc., a Delaware corporation (the "Company"), will be held at
the offices of the Company, 502 South Rosa Road, Madison, Wisconsin 53719 on
June 10, 200314, 2005, at 9:00 a.m., local time, for the following purposes:

          (1) To elect three directors eachone director to serve for a term of three years expiring
     upon the 20062008 annual meeting of shareholders or until their
     successors arehis successor is
     elected and qualified;

          (2) To ratify the appointment of Ernst & Young LLP as the independent
     auditorsregistered public accounting firm of the Company for the year ending
     December 31, 2003;2005; and

          (3) To transact any other business whichthat is properly presented at the
     meeting.

     The foregoing items of business are more fully described in the proxy
statement accompanying this notice. Only shareholders of record at the close of
business on April 18, 200315, 2005, are entitled to notice of and to vote at this
meeting.

     All shareholders are invited to attend the meeting in person. However, to
assure your representation at the meeting, you are urged to sign and return the
enclosed proxy as promptly as possible in the postage prepaid envelope enclosed
for that purpose. Any shareholder entitled to vote and attending the meeting may
vote in person even if a proxy is returned.

                                          By Order of the Board of Directors,

                                          /s/ LANCE FORS, PH.D

                                          Lance Fors, Ph.D
                                          Chairman of the Board and
                                          Chief Executive OfficerJOHN J. PUISIS
                                          John J. Puisis

April 25, 200329, 2005


                         THIRD WAVE TECHNOLOGIES, INC.
                             ---------------------

                            PROXY STATEMENT FOR THE
                    20032005 ANNUAL MEETING OF THE SHAREHOLDERS
                                 JUNE 10, 200314, 2005
                             ---------------------
                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

     The enclosed proxy is solicited on behalf of Third Wave Technologies, Inc.
(the "Company", "us", "we" or "our") for use at the annual meeting of
shareholders to be held on Tuesday, June 10, 200314, 2005, at 9:00 a.m., local time, or
at any adjournment or adjournments thereof, for the purposes set forth herein
and in the accompanying notice of annual meeting of shareholders. The annual
meeting will be held at the principal executive offices of the Company at 502
South Rosa Road, Madison, Wisconsin 53719. The telephone number at that location
is (608) 273-8933.

     These proxy solicitation materials are being mailed on or about April 25,
2003May 6,
2005, to all shareholders entitled to vote at the meeting.

RECORD DATE

     Shareholders of record at the close of business on April 18, 2003,15, 2005, the
record date for the meeting, are entitled to notice of and to vote at the
meeting. At the record date, 39,578,77441,154,491 shares of the Company's common stock
were issued and outstanding.

REVOCABILITY OF PROXIES

     Any proxy given pursuant to this solicitation may be revoked by the person
giving it at any time before its use by delivering to the Company a duly
executed proxy bearing a later date, by attending the shareholder meeting and
voting in person, or by delivering to the Secretary of the Company, at the
Company's principal executive offices, a written notice of revocation.

VOTING AND SOLICITATION

     Each shareholder is entitled to one vote for each share held as of the
record date for the meeting. Shareholders will not be entitled to cumulate their
votes in the election of directors.

     The cost of soliciting proxies will be borne by the Company. The Company
expects to reimburse brokerage firms and other persons representing beneficial
owners of shares for their expenses in forwarding solicitation material to such
beneficial owners. Proxies may also be solicited by certain of the Company's
directors, officers and employees, without additional compensation, personally
or by telephone, telegram, facsimile or other means of communication. We have
engaged Georgeson & Co. to assist us in distributing materials for a fee
estimated at $5,000, plus reimbursement of out-of-pocket expenses.

QUORUM; ABSTENTIONS; BROKER NON-VOTES

     Votes cast by proxy or in person at the annual meeting will be tabulated by
the inspector of elections appointed for the meeting and will determine whether
a quorum is present.

     We need a majority of the shares of common stock issued and outstanding on
the record date present, in person or by proxy, to have a quorum to allow us to
hold the annual meeting. Shares that are voted "For","For," "Against" or "Abstain"
with respect to any matter are treated as being present at the meeting.


     In the election of directors, you can withhold your vote for any nominee.
Withheld votes will be excluded entirely from the vote on the election of
directors and will have no effect on the outcome. On the ratification of the
appointment of Ernst & Young LLP, you can vote to "abstain". If you vote to
"abstain","abstain," your vote will have the effect of a vote against the ratification.

     If you hold shares through a broker, follow the voting instructions you
receive from your broker. If you do not submit voting instructions with respect
to a matter and your broker does not vote your shares on that matter (so-called
"broker non-votes"), your shares will not be counted in determining the outcome
of the vote on that matter.

     Any proxy that is returned using the form of proxy enclosed and whichthat is not
marked as to a particular item will be voted for the election of the three
nomineesnominee
named in this proxy statement, for the ratification of the appointment of the
independent auditors, and as the proxy holders deem advisable on other matters
that may come before the meeting, as the case may be, with respect to the items
not marked.

DEADLINE FOR RECEIPT OF SHAREHOLDER PROPOSALS

     Proposals of shareholders that are intended to be presented by those
shareholders at the Company's annual meeting to be held in 20042006 must be
submitted in writing to the Secretary of the Company at the Company's executive
offices and received by the Company no later than December 26, 200330, 2005, in order
that those proposals may be considered for possible inclusion in the proxy
statement relating to that meeting.

     In addition, the by-laws of the Company provide that any shareholder
entitled to vote may nominate persons for election as directors or propose
business to be brought before a meeting, or both, only if the shareholder has
given timely notice in proper written form of the shareholder's intent to make a
nomination or propose business. To be timely, the shareholder's notice must be
delivered to or mailed and received at the principal executive offices of the
Company not less than 120 days in advance of the first anniversary date of the
mailing of the Company's proxy statement released to shareholders in connection
with the previous year's annual meeting of shareholders, unless no annual
meeting was held in the previous year or the date of the annual meeting has been
changed by more than 30 days from the date contemplated at the time of the
previous year's proxy statement, in which case, to be timely such notice must be
so received a reasonable time before the solicitation is made. The by-laws
contain provisions regarding information that must be set forth in the
shareholder's notice in order for it to be in proper form.

                                 PROPOSAL NO. 1

                             ELECTION OF DIRECTORS

     The Company's board of directors currently consists of nine persons,
divided into three classes serving terms of three years. Shareholders elect one
class of directors at each annual meeting. Three directors areOne director is to be elected at this
annual meeting each to hold office until the 20062008 annual meeting of shareholders or
until a successor has been duly elected and qualified. The other classes of
directors will be elected at the Company's annual meetings of shareholders to be
held in 20042006 and 2005.2007.

     If any of the nomineesnominee for director at the annual meeting becomes unavailable or
declines to serve as a director at the time of the annual meeting, the proxy
holders will vote the proxies in their discretion for any nominee who is
designated by the current board of directors to fill the vacancy. We do not
expect any of the nomineesnominee to be unavailable to serve.

     The namesname of the three nomineesnominee for election to the board of directors at the
annual meeting, their ageshis age as of the record date for the meeting, and certain
information about them arehim is set forth below. The names of the current directors
with unexpired terms, their ages as of the record date, and certain information
about them also are also stated below.

     Mr. Burrill and Dr. Smith's terms as directors expire at the annual meeting
of shareholders on June 14, 2005, and they are not being renominated. The board
has not nominated replacement board members because of timing. It is actively
conducting a search for new board members to replace Mr. Burrill and Dr. Smith
when
                                        2


NOMINEES FOR ELECTION AT THE ANNUAL MEETING FOR TERMS ENDING IN 2006

NAME AGE PRINCIPAL OCCUPATION - ---- --- ------------------------------------------- John Neis(1)(2)(3)........................ 47 Senior Partner, Venture Investors Management LLC Sam Eletr, Ph.D. ......................... 64 Retired; Former Chairman and CEO of Applied Biosystems. Gordon F. Brunner......................... 64 Partner, Living Longer Proactive Health; retired Senior Vice President, Chief Technology Officer, and member of the Board of Directors of Procter & Gamble Co.
their terms expire. The board highly values the long service and many contributions of Mr. Burrill and Dr. Smith and seeks to appoint highly-qualified board members that will provide leadership in achieving the company's long-term strategic goals. The proxies cannot be voted for a greater number of persons than the number of nominees named. DIRECTORS CONTINUING IN OFFICE - TERMS ENDING IN 2004
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Lance Fors, Ph.D.......................... 45 Chairman of the Board, President and Chief Executive Officer, Third Wave Technologies, Inc. David A. Thompson(3)...................... 61 Retired; Former Senior Vice President & President, Diagnostic Division, Abbott Laboratories Kenneth R. McGuire........................ 61 Chief Executive Officer, Burbank Group of Companies
DIRECTORS CONTINUING IN OFFICE - TERMS ENDING IN 2005
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Tom Daniel(1)(2)(3)....................... 38 Partner, Schroder Ventures G. Steven Burrill(2)...................... 5860 Chief Executive Officer, Burrill & Company Lloyd M. Smith, Ph.D.(1)(3)............... 48 KellettPh.D...................... 50 John D. MacArthur Professor of Chemistry, University of Wisconsin, Director of the Genome Center at the University of Wisconsin-Madison and Member, Scientific Advisory Board, Third Wave Technologies, Inc. Lionel Sterling(2)........................ 67 President, Equity Resources, Inc.
DIRECTORS - TERMS ENDING IN 2006
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Gordon F. Brunner(1)(3)................... 66 Retired; Former Senior Vice President, Chief Technology Officer, and member of the Board of Directors of Procter & Gamble Company; Partner, Cincinnati Living Longer ProActive Health Center Sam Eletr, Ph.D.(3)....................... 66 Retired; Former Chairman and CEO of Applied Biosystems John Neis(1)(2)........................... 49 Senior Partner, Venture Investors LLC
DIRECTORS - TERMS ENDING IN 2007
NAME AGE PRINCIPAL OCCUPATION - ---- --- -------------------- Lance Fors, Ph.D. ........................ 47 Chairman of the Board, Third Wave Technologies, Inc. John J. Puisis............................ 45 President and Chief Executive Officer, Third Wave Technologies, Inc. David A. Thompson(1)(3)................... 63 Retired; Former Senior Vice President & President, Diagnostic Division, Abbott Laboratories
- --------------- (1) Member of the compensation committee (2) Member of the audit committee (3) Member of the nominating and governance committee There are no family relationships among any of the directors or executive officers of the Company. NOMINEESNOMINEE FOR ELECTION AT THE JUNE 14, 2005 ANNUAL MEETING FOR TERMSTERM ENDING IN 20062008 Lionel Sterling was appointed to the Third Wave board of directors in August 2004. Mr. Sterling is president of Equity Resources, Inc., a private investment firm. He previously co-founded and served as managing partner of the private investment firm Whitehead/Sterling. Mr. Sterling serves on a number of corporate and philanthropic boards. He most recently served on the Board of I-STAT Corporation. He also has served as chairman of the Board of Directors of Rayovac Corporation, Executive Vice President and Director of United Brands Company, and Sector Executive and Chief Financial Officer of American Can Company. He also held various investment and financial positions at Donaldson, Lufkin & Jenrette Inc. and ITT Corporation. Mr. Sterling holds an M.B.A. from New York University. 3 THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE NOMINEE SET FORTH ABOVE. DIRECTORS WHOSE TERMS EXTEND BEYOND THE ANNUAL MEETING John Neis has served as one of our directors since August 1994. Mr. Neis is Senior Partner of Venture Investors Management LLC, a firm that is the manager and general partner of Madison, Wisconsin-based venture capital management funds. He also serves on the Board of Directors of TomoTherapy, Inc., Deltanoid Pharmaceuticals, Inc., NimbleGen Systems, Inc., and the Wisconsin Technology Council, and on the Advisory BoardBoards of the Weinert Applied Ventures Program and Tandem Press at the University of Wisconsin.Wisconsin-Madison. Mr. Neis received a B.S. in finance from the University of Utah and an M.S. in business from the University of Wisconsin,Wisconsin-Madison, and is a Chartered Financial Analyst. Gordon F. Brunner has served as one of our directorsa director since January 2003. Mr. Brunner is currently a partner with Living Longer Proactive Health and was senior vice president, chief technology officer, head of worldwide research and development, andserved as Chief Technology Officer as well as a member of the board of directors of the Procter & Gamble Co.Company, until his retirement after 40 years of service. He has more than 40 years'extensive experience leveraging innovative technology platforms to the pharmaceutical, over-the-counter and consumer markets. He earnedreceived a B.S. degree in biochemical engineering from the University of Wisconsin-Madison, and an M.B.A. degree from Xavier University. 3 Mr. Brunner is a partner in the Cincinnati Living Longer ProActive Health Center and serves as a director of two other public companies, Scotts Miracle-Gro Corporation, and Natrol, Inc., as well as privately-held Iams Imaging and Beverage Holdings, L.L.C. He also serves on the boards of Christ Hospital (Cincinnati, Ohio), the Wisconsin Alumni Research Foundation, and Xavier University. Sam Eletr, Ph.D., has served as one of our directors since June 2002. Dr. Eletr co-founded Applied Biosystems, Inc. and served as its Chairman and Chief Executive Officer.Officer until 1987. Prior to founding Applied Biosytems,Biosystems, Dr. Eletr managed the analytical and medical instruments group at Hewlett-Packard Co.'s corporate research laboratories. Dr. Eletr most recently co-founded and served as chairman and chief executive officer of Lynx Therapeutics Inc., a publicly traded genomics company.company, which recently merged with Solexa. He earnedcurrently serves on the Boards of two privately held companies, Faust Pharmaceuticals, in Strasbourg, France, and SpinX Technologies, in Geneva, Switzerland. He holds an M.A. in physics and a Ph.D. in biophysical chemistry, both atfrom the University of California-Berkeley. THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE NOMINEES SET FORTH ABOVE. DIRECTORS WHOSE TERMS EXTEND BEYOND THE ANNUAL MEETINGCalifornia, Berkeley. Lance Fors, Ph.D., our founder and Chairman of the Board, has served as our President, Chief Executive Officer and one of our directors since our inception in 1993. Dr. Fors served as our President from 1993 until 2003 and our Chief Executive Officer until 2004. Dr. Fors received his Ph.D. in molecular biology from the California Institute of Technology in 1990. Dr. Fors has more than over twenty years of research and development experience and is the inventor on 1913 issued and pending patents in the area of DNA and RNA sequence analysis. David A. Thompson has served as one of our directors since August 1997. Mr. Thompson retired from Abbott Laboratories in 1995, where he worked for overmore than 30 years. He held several corporate officer positions with Abbott Laboratories, including: Senior Vice President & President Diagnostic Division 1983-1995, Vice President Human Resources 1982-1983, Vice President Corporate Materials Management 1981-1982 and Vice President Operations 1974-1981. Mr. Thompson currently serves on the board of directors of St. Jude Medical Inc., a medical device company. Kenneth R. McGuireJohn J. Puisis, our President and Chief Executive Officer, joined Third Wave as Senior Vice President in September 2001. Since that time, Mr. Puisis also has served as oneour Chief Financial Officer and Chief Operating Officer. Mr. Puisis was appointed to our board of our directors since October 1998. In 1986,in February 2004. From 1996 until he joined the Company, Mr. McGuire foundedPuisis held senior management positions at the first ofSpencer Stuart and Egon Zehnder executive recruitment firms, specializing in recruiting for the Burbank Group of Companies, manufacturers of commercial aircraft noise suppression equipment. He has served as Chief Executive Officer of the member companies of the Burbank Group since their respective inceptions.biotechnology and pharmaceutical industries. From 1989 to 1996, Mr. McGuire received a B.S. from the United States Naval AcademyPuisis held key financial executive positions at DEKALB Genetics and a J.D. from Columbia University. Tom Daniel has served as one of our directors since October 1999. He is General Partner with Schroder Ventures Life Sciences, a venture capital investment firm, where he has focused on life science investments in the United States and Europe since 1998. From 1995Kraft Foods. Prior to 1998,1989, Mr. Daniel was an associate with Domain Associates, a United States venture capital firm focused on the life sciences. Before Domain,Puisis held various positions at several large public accounting firms. Mr. Daniel worked for Charles River Ventures, a United States venture capital firm focused on biotechnology investments. Mr. Daniel is a director of Oxagen and Solexa and is responsible for investments in Cellzome, Sunesis and a number of other private and public companies. Mr. DanielPuisis received an M.B.A. from Harvard Business School, wasNorthwestern University and a member of a genetics research team at the University of North Carolina, Chapel HillB.A. in accounting from 1983-1984, and has an M.A. in Biological Sciences from OxfordNorthern Illinois University. G. Steven Burrill has served as one of our directors since October 1998. Mr. Burrill is Chief Executive Officer of Burrill & Company, a Life Sciences Private Merchant Bank which he founded in 1994. Prior to founding Burrill & Company, Mr. Burrill was a partner of Ernst & Young from 1977 through 1993. Mr. BurrillHe is a director of DepoMed, Galapagos Genomics, and Targacept. He currently serves as Board Chairman for Paradigm Genetics and Pyxis Genomics. Mr. Burrill received a B.B.A. from the University of Wisconsin, Madison. Lloyd M. Smith, Ph.D. has served as one of our directors since our formation and also serves on our scientific advisory board. Dr. Smith is Kellett Professor of Chemistry and Director of the Genome Center at the University of Wisconsin, Madison. Dr. Smith was the primary inventor of automated DNA sequence analysis. Dr. Smith regularly consults and advises us in our research and development efforts. He is chair of the scientific advisory boards of ProCognia Ltd. and GenTel Corporation and a member of the scientific advisory board of Curagen Corporation.certified public accountant. 4 VOTE REQUIRED Directors are elected by a plurality of the votes cast. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the three nominees.nominee. Votes withheld from any director will have no effect on the outcome. 4 BOARD MEETINGS, COMMITTEES AND DIRECTOR COMPENSATION The board of directors provides oversight with respect to the Company's strategic direction and significant corporate policies. Of the nine directors, all but Dr. Fors, Dr. Smith and Mr. Puisis are "independent" as such term is defined in the listing standards of the National Association of Securities Dealers. The board of directors has three standing committees: a compensation committee, an audit committee, and a nominating and governance committee. From time to time, the board has created various ad hoc committees for special purposes. The board of directors held a total of sixnine meetings during 20022004 and all directors attended at least 75%97% of the total number of meetings of the board and committees of the board on which the director served during 2002.2004. The Company encourages but does not require its directors to attend the annual meeting of the shareholders. Three directors attended the 2004 annual meeting of the shareholders. Shareholders may communicate with our board of directors, haseither as a compensation committee,whole or with an audit committee and a nominating committee. From time to time,individual member, by following the board has created various ad hoc committees for special purposes.procedures set forth on our website www.twt.com. COMPENSATION COMMITTEE The compensation committee consists of Messrs. Smith,Brunner, Neis and Daniel.Thompson. The board of directors has determined that each member of the compensation committee is "independent" as such term is defined in the listing standards of the National Association of Securities Dealers. The compensation committee makes recommendations to the board of directors regarding our employee benefit plans and the compensation of officers. The compensation committee held a total of four meetingsone meeting during 2002.2004. The board of directors has adopted a compensation committee charter, which is available at the Company's website www.twt.com. AUDIT COMMITTEE The audit committee appoints our independent auditors, directs the scope of the audit of our financial statements and other services provided by our independent auditors, reviews the accounting principles and procedures to be used for financial statements and reviews the results of the audit. The audit committee also is responsible for the pre-approval of all services provided by our independent auditors. The audit committee consists of Messrs. Neis, Burrill and Daniel. EachSterling. The board of directors has determined that each member is "independent" as such term is defined in the listing standards of the National Association of Securities Dealers. The audit committee makes recommendations to the board of directors regardingalso has determined that all committee members are audit committee financial experts as such term is defined by the selectionrules of independent auditors, reviews the scopeSecurities and Exchange Commission. The board of audit and other services by our independent auditors, reviewsdirectors has adopted an Audit Committee Charter, which is available at the accounting principles and auditing practices and procedures to be used for our financial statements and reviews the results of those audits.Company's website www.twt.com. Information regarding the functions performed by the audit committee and the number of meetings held during 20022004 is set forth in the "Report of the Audit Committee",Committee," included in this proxy statement. The nominating committee consists of Messrs. Daniel, Neis, Smith and Thompson.NOMINATING COMMITTEE The nominating committee evaluates and recommends candidates for election or appointment to the board of directors. The nominating committee held four meetingshas not established any specific, minimum qualifications that any candidate for director must meet, but considers a wide array of factors, including the candidate's knowledge of our industry, the candidate's educational and professional experience as well the candidate's reputation. The nominating committee met three times in 2002.2004. The board of directors has adopted a Nominating Committee Charter, which is available at the Company's website www.twt.com. 5 The nominating committee consists of Messrs. Eletr, Brunner, and Thompson. The board of directors has determined that each member of the nominating committee is "independent" as such term is defined in the listing standards of the National Association of Securities Dealers. The nominating committee will consider director candidates recommended by shareholders. Recommendations may be sent to John Comerford,Kevin T. Conroy, Vice President, General Counsel and Secretary, 502 South Rosa Road, Madison, Wisconsin 53719. Any recommendation submitted by a shareholder must include the name and address of the shareholder, any arrangements between the shareholder and the candidate pursuant to which the candidate is being nominated, and any information that would be required under the rules of the Securities and Exchange Commission to be included in the Proxy Statement had the candidate been nominated by the board of directors. The nominating and governance committee will apply the same standards in considering candidates submitted by shareholders as it applies to other candidates. COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION None of the members of the compensation committee is currently, or has ever been at any time since our formation, an officer or employee of the Company or any of its subsidiaries. No member of the compensation committee serves as a member of the board of directors or compensation committee of any entity that has one ofor more officers serving as a member of our board of directors or compensation committee. DIRECTOR COMPENSATION Upon initial election, our non-employee directors receive a stock option grant of 30,000 options. The price of these options is determined by the fair market value of the companyCompany stock on the date of grant. Following the third year ofafter initial election, our non-employee directors receive an annual grant of 10,000 options. OptionsThe initial options vest at 25% peron a three-year vesting schedule and the annual option grants vest in one year on the anniversary date of the option grant and accelerate upon a change of control of the Company consistent with the terms outlined in the company'sCompany's stock option grant agreements. Our non-employee directors receive an annual retainer of $12,000,$40,000, a board meeting fee of $1,500 for regularly scheduled board meetings physically attended and a board$500 for each meeting attended by teleconference. The lead director, David Thompson, and committee meeting participation feechair directors receive an annual retainer of $500 per meeting.$7,500 and directors who hold committee positions receive an annual retainer of $5,000. Our directors are reimbursed for allreasonable director-related expenses incurred as a result of providing service to the companyCompany or at the company'sCompany's request. PROPOSAL NO. 2 RATIFICATION OF APPOINTMENT OF AUDITORSINDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM The board of directors has, based on the determination of the audit committee has appointed Ernst & Young LLP as the independent auditorsregistered public accounting firm of the Company for the current fiscal year ending December 31, 2003.2005. Ernst & Young LLP havehas audited the Company's financial statements since its inception. 56 FEES PAID OR DUE TO ERNST & YOUNG LLP Audit Fees.In addition to retaining Ernst & Young LLP to audit our financial statements, we engage it from time to time to perform other services. The aggregatetable below shows the total fees for professional services renderedbilled by Ernst & Young LLP for its services in connection with their 2002 annual2003 and 2004.
FEE TYPE FISCAL 2003 FISCAL 2004 - -------- ----------- ----------- Audit Fees*................................................. $189,650 $488,800 Audit Related Fees**........................................ $ 1,500 $ 1,500 Tax Fees**.................................................. $ 40,450 $ 32,895 All Other Fees**............................................ 0 0 -------- -------- Total....................................................... $231,600 $523,195 ======== ========
- --------------- * Includes fees and expenses related to the fiscal year audit and interim reviews, notwithstanding when the fees and expenses were billed or when the services were rendered. For 2004, the audit fees also include the audit of our internal control over financial statements in our Quarterly Reports on Form 10-Qreporting as required by Section 404 of the Sarbanes-Oxley Act. ** Includes fees and expenses for 2002services rendered from January through December of the fiscal year, notwithstanding when the fees and expenses were approximately $261,500. Financial Information Systems Design and Implementation Fees.billed. The Company did not engageaudit committee has considered whether the provision of the non-audit services described above is compatible with maintaining the independence of Ernst & Young LLP and determined that such services are compatible with maintaining independence. The audit committee has adopted a policy that requires pre-approval by the audit committee of all services to undertake any financial information systems design and implementation work during 2002. All Other Fees.be provided by the Company's independent registered public accounting firm. The aggregate fees for all otheraudit committee has approved the provision of audit services rendered by Ernst & Young LLP for fiscal year 2005 in 2002 was approximately $51,020, consistingaccordance with that policy. All other services to be provided by the Company's independent auditor must be specifically pre-approved by the audit committee or a designated member of the audit related services of approximately $15,145 and non-audit services of approximately $35,875. Audit related services generally include fees for accounting consultations and registration statements.committee. Representatives of Ernst & Young LLP are expected to be present at the annual meeting with the opportunity to make a statement if they desire to do so and are expected to be available to respond to appropriate questions. If shareholders fail to ratify the selection, the audit committee and the board will reconsider whether or not to retain that firm. Even if the selection is ratified, the audit committee and the board in theirits discretion may direct the appointment of a different independent auditorsregistered public accounting firm at any time during the year. THE COMPANY'S BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS THE COMPANY'S INDEPENDENT AUDITORSREGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2003.2005. VOTE REQUIRED The ratification of the appointment of Ernst & Young LLP requires the affirmative vote of a majority of the shares of common stock represented at the annual meeting and entitled to vote thereon. 67 EXECUTIVE COMPENSATION SUMMARY COMPENSATION TABLE The following table sets forth the compensation paid by us during 2000, 20012004, 2003 and 2002 to our chief executive officer, executive chairman and our next four most highly compensated other executive officers who received salary compensation of more than $100,000 during 20022004 (the "Named Executive Officers"). SUMMARY COMPENSATION TABLE
LONG-TERM COMPENSATION --------------- ANNUAL COMPENSATION SECURITIES ------------------------------------------------------- UNDERLYING ALL OTHER NAME PRINCIPAL POSITION(S) YEAR SALARY($) BONUS($) OPTIONS/SARS(#) COMPENSATION($) - ---- --------------------- ---- --------- ------------------ --------------- --------------- John J. Puisis(1)........ President, 2004 $440,305 $286,000 29,333 $20,987(1) Chief Executive 2003 $349,798 $200,000 480,000 $24,246(2) Officer, Director 2002 $253,380 $150,000 145,000 $26,106(3) Dr. Lance Fors......... President,Fors........... Executive Chairman, 2004 $474,254 $ 0 10,000 $58,857(4) Director, and Former 2003 $430,523 $200,000 220,000 $98,540(5) Chief Executive 2002 $398,239 $150,000 291,000 $ 2,826(2) Executive7,824(6) Officer 2001 $384,790 $0 141,480 Chairman, Director 2000 $317,513 $166,600 693,600 John J. Puisis(1)......Ivan Trifunovich......... Senior Vice President 2004 $269,972 $106,000 32,000 $ 6,500(7) 2003 $263,693 $ 85,750 0 $ 6,000(7) 2002 $253,380 $150,000 145,000 $20,705(2) President, Chief 2001$260,713 $ 65,587 $2,111,864 275,0000 100,000 $ 4,924(2) Financial Officer, Chief Operating Officer Dr. Bruce Neri.........5,500(7) Maneesh Arora(8)......... Senior Vice 2002 $247,549 $75,000 145,000 President 2004 $278,134 $ 75,000 68,333 $28,887(9) 2003 $206,739 $110,000 350,000 $26,819(10) Vecheslav Elagin(11)..... Vice President 2004 $177,298 $110,000 198,500 $ 6,500(7) Research 2001 $221,987 $0 59,400 & Development 2000 $193,734 $68,750 62,400 Ivan Trifunovich(3).... Senior Vice 2002 $260,713 $0 100,000 President & 20012003 $ 61,214 $ 0 $0 210,000 General Manager, Genomics Business Unit John Comerford(4)......58,000 $52,472(12) Development Jacob Orville(13)........ Vice President, 2004 $199,385 $ 60,000 16,000 $ 6,500(7) Global Sales 2003 $161,445 $ 40,000 210,000 $ 6,000(7) 2002 $209,879 $15,000 140,000 General Counsel & 2001 $200,461 0 81,000 Secretary 2000 $ 53,539 $21,678 39,60098,527 $ 11,850 40,000 $28,603(14)
- --------------- (1) Mr. Puisis joined us in September 2001. (2) Consists ofRepresents payment for relocation expenses paid by us.and the Company's matching contribution to a 401(k) plan of $14,487 and $6,500, respectively. (2) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $18,246 and $6,000, respectively. (3) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $20,706 and $5,400, respectively. (4) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $52,357 and $6,500, respectively. (5) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $92,540 and $6,000, respectively. (6) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $2,826 and $4,998, respectively. (7) Represents the Company's matching contribution to a 401(k) plan. (8) Mr. TrifunovichArora joined usthe Company in December 2001. (4)January 2003 (9) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $22,387 and $6,500, respectively. (10) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $21,437 and $5,382, respectively. (11) Mr. ComerfordElagin joined usthe Company in September 2000.June 2003 and became Vice President of Research & Development in October 2004. 8 (12) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $50,777 and $1,695, respectively. (13) Mr. Orville joined the Company in April 2002 and became Vice President of Global Sales in October 2003. (14) Represents payment for relocation expenses and the Company's matching contribution to a 401(k) plan of $25,844 and $2,759, respectively. OPTION GRANTS IN 20022004 The following table sets forth information relating to stock options granted during 20022004 to the Named Executive Officers. In accordance with the rules of the Securities and Exchange Commission, also shown below is the potential realizable value overduring the term of the option (the period from the grant date to the expiration date) based on assumed rates of stock appreciation of 5% and 10%, compounded annually. These amounts are mandated by the Securities and Exchange Commission and do not represent our estimate of 7 future stock price. Actual gains, if any, on stock option exercises will depend on the future performance of our common stock.
INDIVIDUAL GRANTS ----------------------------------------------------- POTENTIAL REALIZABLE PERCENT OF POTENTIAL REALIZABLE VALUE AT ASSUMED NUMBER OF TOTAL ASSUMED ANNUAL RATES OF STOCK SECURITIES OPTIONS STOCK PRICE APPRECIATION FOR UNDERLYING GRANTED TO EXERCISE OPTION TERM OPTIONS EMPLOYEES IN PRICE PER EXPIRATION ---------------------------------------------------- NAME GRANTED(#)(1) 2002(2)2004(2) SHARE($) DATE 5%($) 10%($) - ---- ------------- ------------ --------- ---------- ------------- ------------------------- -------- Dr. Lance Fors....... 291,000 12.61 2.13 6/12/2012 389,808 987,849Fors......... 10,000 .47% 7.82 11/04/2014 49,180 124,631 John J. Puisis....... 145,000 6.28 2.13 6/12/2012 194,234 492,227 Dr. Bruce Neri....... 145,000 6.28 2.13 6/12/2012 194,234 492,227Puisis......... 29,333 1.38% 3.37 02/25/2014 62,168 157,545 Maneesh Arora.......... 68,333 3.21% 3.37 02/25/2014 144,823 367,011 Ivan Trifunovich..... 100,000 4.33 2.13 6/12/2012 133,955 339,467 John Comerford....... 140,000 6.07 2.13 6/12/2012 187,536 475,254Trifunovich....... 32,000 1.50% 3.37 02/25/2014 67,820 171,869 Vecheslav Elagin....... 108,500 5.10% 3.37 02/25/2014 229,952 582,744 50,000 2.35% 3.19 07/26/2014 100,309 254,202 40,000 1.88% 6.88 10/28/2014 173,072 438,598 Jacob Orville.......... 16,000 .75% 3.37 02/25/2014 33,910 85,935
- --------------- (1) For each of the Named Executive Officers, 25% of the options vest on each of the first four anniversaries of the grant date.date with the exception of Lance Fors whose options vest in one year. (2) WeDuring 2004, we granted options to purchase a total of 2,307,9502,127,255 shares of common stock during 2002.stock. 9 AGGREGATE OPTION EXERCISES IN 20022004 AND FISCAL YEAR-END OPTION VALUES The following table sets forth information for the Named Executive Officers relating to option exercises in 20022004 and the number and value of securities underlying exercisable and unexercisable options held at December 31, 2002:2004:
NUMBER OF SECURITIES UNDERLYING UNEXERCISED VALUE OF UNEXERCISED OPTIONS AT IN-THE-MONEY OPTIONS AT SHARES DECEMBER 31, 20022004 DECEMBER 31, 2002(1)2004($)(1) ACQUIRED ON VALUE --------------------------- --------------------------- NAME EXERCISE(#) REALIZED($) EXERCISABLE UNEXERCISABLE EXERCISABLE UNEXERCISABLE - ---- ----------- ------------------------- ----------- ------------- ----------- ------------- Dr. Lance Fors.......Fors......... 0 0 601,770 674,310 99,792 119,310677,100 320,500 2,123,661 1,681,785 John Puisis..........J. Puisis......... 0 0 275,000 145,000 59,450 Dr. Bruce Neri.......398,750 530,583 1,593,338 2,713,774 Maneesh Arora.......... 0 0 181,650 214,750 184,800 59,45087,500 330,833 470,000 1,767,382 Ivan Trifunovich.....Trifunovich....... 0 0 52,500 257,500 41,000 John Comerford.......207,500 134,500 658,975 602,685 Vecheslav Elagin....... 0 0 48,750 211,850 57,40014,500 242,000 71,770 1,122,065 Jacob Orville.......... 0 0 72,500 193,500 388,625 983,225
- --------------- (1) Value of unexercised in-the-money options are based on a value of $2.54$8.60 per share, the fair market value of our common stock on December 31, 2002.2004. Amounts reflected are based on the value of $2.54$8.60 per share, minus the per share exercise price, multiplied by the number of shares underlying the option. EMPLOYMENT AGREEMENTS WITH EXECUTIVE OFFICERS We haveIn October of 2003 we entered into a three-year employment agreement with Dr. Fors, then CEO, that provided for an initial base salary of $400,000. The agreement also provided that Dr. Fors' employment could be terminated at any time by us or by Dr. Fors. In June of 2004, in connection with the transition in his role from Chairman and CEO to Executive Chairman, we amended Dr. Fors' employment agreement. The amended agreement provides for a base salary of $400,000, comprised of $133,000 per year for Executive Chairman services ("Base Compensation") and $267,000 per year as a severance obligation ("Severance Compensation") associated with his transition from CEO to Executive Chairman. The term of his agreement is through June 30, 2007 unless terminated sooner by either party. If Dr. Fors' employment as Executive Chairman is terminated by us other than for "cause" (as defined in the agreement) or Dr. Fors voluntarily terminates his employment for "good reason" (as defined in the agreement), Dr. Fors would receive severance payments totaling (i) the greater of the remaining Base Compensation or 24 months of Base Compensation, (ii) the remaining Severance Compensation, (iii) compensation intended for medical and insurance expense equal to $30,400, (iv) an outplacement consulting package for Dr. Fors up to a maximum of $15,000. In September of 2001, we entered into an employment agreement with Mr. Puisis that providesprovided for an initial base salary of $225,000 and a target annual bonus of nonot less than 22.5% of base salary. The agreement provided for an initial option grant to Mr. Puisis and for the one-time sign-on bonus to Mr. Puisis (the "Sign-on Bonus") listed under "Summary Compensation Table" to partially compensate Mr. Puisis for certain moneysmonies lost upon Mr. Puisis beginning employment with us. Mr. Puisis' employment may be terminated by either us or Mr. Puisis at any time, except that (i) if we terminate Mr. Puisis for "cause" (as definedagreement was amended in July of 2003 to accelerate the vesting of his stock options in the employment agreement)event of termination without "cause" or Mr. Puisis voluntarily terminates his employment other thanresignation for "good reason" (as definedreason." Mr. Puisis' employment agreement was amended again in the employment agreement) after the first twelve months but within the first twenty-four months, Mr. Puisis must repay2004 prior to us $700,000 of the Sign-on Bonus and (ii) if we terminate Mr. Puisis other than for "cause" or Mr. Puisis voluntarily terminates his employment for "good reason",promotion to CEO. Under his agreement, Mr. Puisis would, upon termination without "cause" or resignation for "good reason," receive (i) a lump sumlump-sum severance payment equal to onetwo year's base salary, and(ii) a pro-rated portion of his target bonus, (iii) $15,000 outplacement compensation and (iv) continued coverage for one year under our health and other welfare benefit plans. The employment agreement with Mr. Puisis defines "good reason" to include (i) Dr. Fors voluntarily ceasing to be the CEO or Chairman of the 8 board of directors within eighteen months of the beginning of Mr. Puisis' employment and (ii) a resignation by Mr. Puisis following a "change of control" (as defined in the employment agreement). In March of 2005, we entered into employment agreements with Mr. Kevin Conroy, Vice President, General Counsel & Secretary and James Herrmann, Vice President, Finance. Mr. Conroy's employment agreement provides for an initial base salary of $225,00. Mr. Herrmann's agreement provides for an initial base salary of $190,000. The agreements provide that employment may be terminated at any time by either the 10 executive or the company. If the agreements are terminated by us other than for "cause" (as defined in the agreement) or the executive voluntarily terminates his employment for "good reason" (as defined in the agreement), the executive would receive (i) an amount equal to one year's base salary, (ii) in the event that the termination occurs within one year following a change of control (as defined in the employment agreements), a pro-rated target bonus, (iii) twelve months of health insurance premiums, (iv) $10,000 of outplacement consulting fees, (v) earned but not earlier than six months after the changeunpaid bonuses and (vi) earned but unpaid long term-incentive plan payments (as "earned" is defined in control.those plans). EQUITY COMPENSATION PLAN INFORMATION The following table summarizes the number of outstanding options granted to employees and directors, as well as the number of securities remaining available for future issuance, under our compensation plans as of December 31, 2002.2004.
NUMBER OF SECURITIES REMAINING AVAILABLE FOR FUTURE ISSUANCE NUMBER OF SECURITIES WEIGHTED AVERAGE UNDER EQUITY TO BE ISSUED UPON EXERCISE PRICE COMPENSATION PLANS EXERCISE OF OUT- OF OUTSTANDING (EXCLUDING SECURITIES STANDING OPTIONS, OPTION WARRANTS REFLECTED IN THE PLAN CATEGORY WARRANTS AND RIGHTS AND RIGHTS FIRST COLUMN) - ------------- -------------------- ---------------- --------------------- Equity compensation plans approved by security holders......................... 6,140,859 $5.35 2,801,5877,446,523 $4.55 2,013,365 Equity compensation plans not approved by security holders......................... 0 0 0 --------- ----- --------- Total...................................... 6,140,859 $5.35 2,801,5877,446,523 $4.55 2,013,365 ========= ===== ===================
BOARD COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION The following report is provided to shareholders by the compensation committee of the board of directors: The compensation committee of the board of directors, which is composed of three independent, non-employee directors, is responsible for the administration of the Company's compensation programs. These programs include base salary for executive officers and both annual and long-term incentive compensation programs. The Company's compensation programs are designed to provide a competitive level of total compensation and include incentive and equity ownership opportunities linked to the Company's performance and shareholder return. Compensation Philosophy. The Company's overall executive compensation philosophy is based on a series of guiding principles derived from the Company's values, business strategy and management requirements. These principles are summarized as follows: - Provideprovide competitive levels of total compensation whichthat will enable the Company to attract and retain the best possible executive talent; - Motivatemotivate executives to achieve optimum performance for the Company; - Alignalign the financial interest of executives and shareholders through equity-based plans; and - Provideprovide a total compensation program that recognizes individual contributions as well as overall business results. Compensation Program. The compensation committee is responsible for reviewing and recommending to the board the compensation and benefits of all officers of the Company and establishes and reviews general policies relating to compensation and benefits of employees of the Company. The compensation committee also is also responsible for the administration of the Company's 2000 Stock Plan. There are two major components to the Company's executive compensation: base salary and potential cash bonus, as well as potential long-term 11 compensation in the form of stock options.options and a long-term incentive plan. The compensation committee considers the total current and potential long-term compensation of each executive officer in establishing each element of compensation. 1. Base Salary. In setting compensation levels for executive officers, the compensation committee reviews competitive information to compensation levels for comparable positions at biotechnology and 9 high technology companies. In addition, the compensation committee may, from time to time, hire compensation and benefit consultants to assist in developing and reviewing overall salary strategies. Individual executive officer base compensation may vary based on time in position, assessment of individual performance, salary relative to internal and external fairness and the critical nature of the position relative to the success of the Company. 2. Annual Incentive Awards. The Company does establish both corporate and individual goals and performance measures consistent with factors necessary to achieve strategic business objectives. Annual incentive awards paid to Company employees, including the executive officers, are determined based on a combination of the achievement of the predetermined corporate and individual performance goals and measures. The annual incentive awards are designed to drive individual and Company performance to enhance shareholder value. 3. Long-Term Incentives. The Company's 2000 Stock Plan provides for the issuance of stock options to officers and employees of the Company to purchase shares of the Company's common stock at an exercise price equal to the fair market value of such stock on the date of grant. Stock options are granted to the Company's executive officers and other employees both as a reward for past individual and corporate performance and as an incentive for future performance. The compensation committee believes that stock-based performance compensation arrangements are essential in aligning the interests of management and the shareholders in enhancing the value of the Company's equity. 3.In January 2004, the Company implemented a long-term incentive plan designed to encourage results-oriented actions on the part of executive officers and other key employees of the Company. A second long-term incentive plan was implemented in February 2005. The plans are intended to align closely the financial rewards for executive officers and key employees with the interests of shareholders and the achievement of specific performance objectives of the Company. The plans are administered by the Compensation Committee, which establishes the term of the plans, performance goals, target awards, performance measurement criteria and calculation of awards. The long-term incentive plans are also designed to reduce reliance on stock option grants as the sole source of long-term incentive compensation. 4. Benefits. The Company provides benefits to the Named Executive Officers that are generally available to all employees of the Company. The amount of executive level benefits and perquisites, as determined in accordance with the rules of the Securities and Exchange Commission relating to executive compensation, did not exceed 10% of total salary and bonus for the calendar year 20022004 for any executive officer. Section 162(m) of the Internal Revenue Code Limitations on Executive Compensation. Section 162(m) of the United States Internal Revenue Code may limit the Company's ability to deduct for United States federal income tax purposes compensation in excess of $1,000,000 paid to the Company's chief executive officer and its four other highest paid executive officers in any one fiscal year. No executive officer of the Company received any such compensation in excess of this limit during fiscal 2002.2004. The total compensation of Dr. Fors,Mr. Puisis, the Company's Chief Executive Officer, is consistent with the Company's overall executive compensation philosophy as described above, and the compensation of Dr. Fors was based on the factors described above. It is the opinion of the compensation committee that the aforementioned compensation policies and structures provide the necessary discipline to properly align the Company's corporate economic performance and the interest of the Company's shareholders with progressive, balanced and competitive executive total compensation practices in an equitable manner. 12 The foregoing report shall not be "soliciting material" or to be "filed" with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing. Respectfully submitted, The compensation committee of the board of directors Lloyd Smith, Ph.D. Tom DanielGordon Brunner John Neis David Thompson EXECUTIVE OFFICERS OF THE COMPANY The executive officers of the Company as of April 25, 200329, 2005 are set forth below: Lance Fors, Ph.D. (45), (47) our founder and Chairman of the Board, has served as our President, Chief Executive Officer and one of our directors since our inception in 1993. Dr. Fors served as our President from 1993 until 2003 and our Chief Executive Officer until 2004. Dr. Fors received his Ph.D. in molecular biology from the California Institute of Technology in 1990. Dr. Fors has overmore than twenty years of 10 research and development experience and is the inventor on 1913 issued and pending patents in the area of DNA and RNA sequence analysis. John J. Puisis (43)(45), our President and Chief Executive Officer, joined Third Wave as Senior Vice President in September 2001. Since that time, Mr. Puisis also has served as our Senior Vice President, Chief Financial Officer since September 2001. In January 2003,and Chief Operating Officer. Mr. Puisis was also assigned the title and dutiesappointed to our board of Chief Operating Officer.directors in February 2004. From 1996 until he joined the Company, Mr. Puisis held senior management positions at the Spencer Stuart and Egon Zehnder executive recruitment firms, specializing in recruiting for the biotechnology and pharmaceutical industries. From 1989 to 1996, Mr. Puisis held key financial executive positions at DEKALB Genetics and Kraft Foods. Prior to 1989, Mr. Puisis held various positions at several large public accounting firms. Mr. Puisis earnedreceived an M.B.A. from Northwestern University and a B.A. in accounting from Northern Illinois University. He is a certified public accountant. Bruce Neri, Ph.D. (56)Maneesh Arora, (36) joined us in July 1996January 2003 as Director of Marketing and was promoted to Vice President of Marketing and Strategy in October 2003. In March 2004 he took on the role of Senior Vice President of Commercial Operations. Prior to joining Third Wave, Mr. Arora was Director of Corporate Strategy and New Ventures for Ondeo Nalco, a $3-billion subsidiary of Suez, a global provider of industrial services. Previous to that, he spent nine years at Kraft Foods in a number of key roles of increasing responsibility in marketing and sales. Mr. Arora received his M.B.A. in marketing and management and strategy from the Kellogg Graduate School of Management and his B.A. in economics from the University of Chicago. James Herrmann (43) joined us as Vice President of ResearchFinance in October 2004 and Developmentassumed responsibility for the Company's finance and accounting functions as our principal financial officer shortly thereafter. After beginning his career at Arthur Andersen, Mr. Herrmann held several senior financial and operations positions at Tribune Company. Immediately prior to joining Third Wave, he was promoted to Senior Vice President of Research and Developmenta general partner in July 1997. From 1991 until joining us, Dr. Neri was Vice President of DNA probe development at Becton, Dickinson and Company. Prior to 1991, Dr. Neri directed Research and Development at Gene-Trak Systems, Angenics, Inc., Instrumentation Laboratories and Abbott Laboratories. Dr. Neri is the inventor on ten United States patents, with an additional 19 pendingelectronics distribution company. Mr. Herrmann received his bachelor's degree in the area of human in-vitro diagnostic products, and over 60 publications. Dr. Neri received a B.A. in chemistry from Cornell College and a Ph.D. in analytical chemistryaccountancy from the University of Arizona.Notre Dame and an M.B.A. from the University of Chicago. He is a certified public accountant. Ivan D. Trifunovich, Ph.D. (39)(41) joined us as Senior Vice President and General Manager of our Genomics business unit in December 2001. From 1999 until joining us, Dr. Trifunovich was, successively,previously held successive positions as Vice President of e-Business and Vice President of Research Strategy and Operations at Pharmacia Corp. Prior to 1999,joining Pharmacia, Dr. Trifunovich was a Director of New Product Marketing at Johnson & Johnson, Inc. From 1992 to 1997, Dr. Trifunovich held various positionsHe began his career at Bristol-Meyers Squibb, Inc. as a bench scientist, where he held several positions of increasing responsibility. Dr. Trifunovich earnedreceived his Ph.D. in organic chemistry at UCLA and hisan M.B.A. at the University of Pennsylvania's Wharton School of Business. He is the holder of ten10 U.S. patents. John Comerford (40)13 Kevin Conroy (39) joined us in September 2000July 2004 as Vice President General Counselof Legal Affairs and Secretary. From 1998 until joining us, Mr. Comerford was Corporateappointed General Counsel and Secretary at Lunar Corporation, a publicly-traded medical device company. From 1990 to 1997, Mr. Comerford was Associate Resident Counsel at National Presto Industries, Inc.in October 2004. Prior to 1990,joining Third Wave, Mr. ComerfordConroy worked for GE Healthcare, where he oversaw the development and management of its information technologies group intellectual property portfolio, and developed and executed litigation, licensing, and corporate product acquisition legal strategies. Before joining GE, Mr. Conroy was an intellectual property litigator at two Chicago law firms, McDermott Will & Emery, and Pattishall, McAuliffe, Newbury, Hilliard and Geraldson, where he was a Staff Attorneypartner. He earned his B.A. in electrical engineering at Fort Howard Corporation. Mr. Comerford received aMichigan State University and his J.D. from Marquettethe University of Michigan. Jacob Orville (31) joined us in April 2002 as Director of Clinical Sales, leading U.S. clinical sales growth of more than 100%, and assumed the role of Vice President of Global Sales in September 2003. Prior to joining us, Mr. Orville held sales and management positions with Smiths Medical. As the National Sales Manger for Smiths, he managed the company's key product line, leading U.S. clinical sales growth of that line from $1 million to more than $30 million. Mr. Orville received his B.A. from the University of Massachusetts. Lander Brown (39) joined us in December 2004 as Vice President of Human Resources and Administration. Mr. Brown's 15-year history in strategic human resources, business process, planning and administration includes the roles of Executive Vice President of Human Resources and member of the U.S. operating board of Leo Burnett USA, Executive Director Human Resources of the Global Specialty Operations group at Pharmacia Corporation, and Vice President of Planning and Administration at the former Moore Corporation, Ltd. Mr. Brown earned his B.A. in social science from Michigan State University and his M.B.A. in human resources management from National-Louis University in Evanston, Illinois. Vecheslav Elagin, Ph.D. (37) joined us in June 2003 as our head of infectious disease research and development and was appointed Vice President, Research and Development in October 2004. Prior to joining Third Wave, Dr. Elagin worked for Visible Genetics Corporation/Bayer HealthCare, where he managed the Hepatitis B and C and HIV product development groups. Before joining Visible Genetics, Dr. Elagin was a senior scientist at Photonic Sensor Corporation; an assistant professor, Department of Biology, University of Notre Dame; and a research scientist at the Institute of Gene Biology in Moscow. Dr. Elagin earned a B.A. in business administrationdegree from St. Norbert College.Moscow Institute of Physics and Technology, an M.B.A. from Vavilov Institute of General Genetics, and a Ph.D. from Engelhard Institute of Molecular Biology. REPORT OF THE AUDIT COMMITTEE The audit committee oversees the Company's financial reporting process on behalf of the board of directors. The audit committee is governed by a written charter approved by the board of directors. Management has the primary responsibility for the financial statements and the reporting process including the systems of internal controls. In fulfilling its oversight responsibilities, the audit committee reviewed with management the audited financial statements in the Company's Annual Report on Form 10-K, the unaudited financial statements in Quarterly Reports on Form 10-Q, and financial result press releases with management including a discussion of the quality, not just the acceptability, of the accounting principles, the reasonableness of significant judgments, and the clarity of disclosures in the financial statements. The audit committee reviewed with the independent auditors, who are responsible for expressing an opinion on the conformity of those audited financial statements with accounting principles generally accepted in the United States, their judgments as to the quality, not just the acceptability, of the Company's accounting principles and such other matters as are required to be discussed with the audit committee under auditing standards generally accepted in the United States. In addition, the audit committee has discussed with the independent auditors the matters required to be discussed by Statement on Auditing Standards No. 61 and the audit committee has discussed with the independent auditors the auditors' independence from management 11 and the Company including the matters in the written disclosures required by the Independence Standards Board Standard No. 1 and considered the compatibility of non-audit services with the auditors' independence. The audit committee discussed with the Company's independent auditors the overall scope and plans for their audit. The audit committee meets with the independent auditors, with and without management present, 14 to discuss the results of their examinations, their evaluations of the Company's internal controls, and the overall quality of the Company's financial reporting. The audit committee held sixseven meetings in 2002.2004. In reliance on the reviews and discussions referred to above, the audit committee recommended to the board of directors (and the board has approved) that the audited financial statements be included in the Company's Annual Report on Form 10-K for the year ended December 31, 2002.2004. The audit committee and the board also have also recommended the selection of the Company's independent auditors. The foregoing report shall not be "soliciting material" or to be "filed" with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing. Respectfully submitted, The audit committee of the board of directors John Neis Lionel Sterling G. Steven Burrill Tom Daniel SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS, DIRECTORS AND MANAGEMENT The following table shows information known to us with respect to the beneficial ownership of our common stock for 5% shareholders as of February 14, 2005, and for officers and directors as of April 18, 200329, 2005 by: - each person (or group of affiliated persons) who owns beneficially 5% or more of our common stock; - each of our directors; - each of the Named Executive Officers; and - all of our directors and executive officers as a group. Except as indicated in the footnotes to this table and subject to community property laws where applicable, the persons named in the table have sole voting and investment power with respect to all shares of our common stock shown as beneficially owned by them. Beneficial ownership and percentage ownership are determined in accordance with the rules of the Securities and Exchange Commission. Addresses for those 15 individuals for which an address is not otherwise indicated is: c/o Third Wave Technologies, Inc., 502 South Rosa Road, Madison, Wisconsin 53719. 12
SHARES BENEFICIALLY OWNED --------------------------------------------- SHARES SUBJECT TO BENEFICIAL OWNER TOTAL NUMBER OPTIONS PERCENTAGE - ---------------- ------------ ----------------- ---------- 5% SHAREHOLDERS: State of Wisconsin Investment Board(1)................ 5,523,000................. 5,345,000 0 13.96% Bank of America Corporation(2)........................ 3,419,45013.14% Mazama Capital Management, Inc.(2)..................... 4,949,684 0 8.64%12.17% NAMED EXECUTIVE OFFICERS AND DIRECTORS: Lance Fors, Ph.D.(3).................................. 2,507,816 601,770 6.24%................................... 2,377,002 677,100 5.68% John Puisis........................................... 293,698 275,000 * Bruce Neri, Ph.D...................................... 202,188 181,650 * Ivan Trifunovich...................................... 52,500 52,500 * John Comerford........................................ 69,824 48,750 *J. Puisis......................................... 531,032 476,083 1.28% G. Steve Burrill(4).................................... 1,071,963 41,100 2.60% Lloyd M. Smith, Ph.D.(4).............................. 2,043,600 16,800 5.16%(5)............................... 1,719,100 41,100 4.17% John Neis(5).......................................... 1,837,125 16,800 4.64%Neis(6)........................................... 1,866,425 41,100 4.53% David A. Thompson..................................... 58,800 58,800Thompson...................................... 94,300 84,300 * Tom Daniel(6)......................................... 1,338,426 16,800 3.38% G. Steven Burrill(7).................................. 1,047,663 16,800 2.65% Kenneth R. McGuire(2)................................. 3,119,850 16,800 7.88% Gordon F. Brunner..................................... 6,000Brunner...................................... 39,500 15,000 * Sam Eletr.............................................. 15,000 15,000 * Lionel Sterling........................................ 21,000 0 * Sam Eletr............................................. 0 0Maneesh Arora.......................................... 166,972 154,583 * Ivan Trifunovich....................................... 215,500 215,500 * Jacob Orville.......................................... 114,004 89,000 * Vecheslav Elagin....................................... 45,560 41,625 * All directors and executive officers as a group (13 persons)............................................ 12,577,490 1,302,470 30.77%............................................. 8,277,358 1,891,491 19.99%
- --------------- * indicates less than 1% (1) Based on information provided in the Schedule 13G filed by the State of Wisconsin Investment Board ("SWIB") with the Securities and Exchange Commission on February 14, 2003.8, 2005. The address of SWIB is P.O. Box 7842, Madison, Wisconsin 53707. (2) Based on information provided in the Schedule 13G filed by Bank of America Corporation ("BAC"), NB Holdings Corporation ("NBH"), Bank of America NA ("BA"), BANA #1 LLC ("BANA") and Bank of America Strategic Solutions,Mazama Capital Management, Inc. ("BASS"MCM") with the Securities and Exchange Commission on February 14, 2003.2005. The Schedule 13G reports that BANAMCM has sole voting power with respect to 2,792,200 of those shares and BASS have shared voting andsole dispositive power with respect to 3,417,4504,949,684 of those shares, BAshares. It does not indicate who has sole vote and dispositivevoting power with respect to 2,000 of those shares, and BAC and NBH have shared voting and dispositive power with respect to all 3,419,450the remaining 2,157,484 shares. The Schedule 13G reports that the shares reported in the Schedule are owned by Mr. McGuire and have been pledged by Mr. McGuire to BA to secure certain obligations under a loan agreement. The address of BACMCM is 100 N. Tryon Street, Charlotte, NC 28255.One S.W. Columbia, Suite 1500, Portland, Oregon 97258. (3) Includes 1,900,8001,699,902 shares of common stock held in a voting trust for the benefit of Dr. Fors' family members. Dr. Fors and his wife, Charlotte H. Selover, are co-trustees of this voting trust. (4) Includes 148,800 shares of common stock held in a voting trust for the benefit of Dr. Smith's family members. Dr. Smith is the sole trustee of this voting trust. (5) Includes 369,787 shares held by Venture Investors of Wisconsin; 269,400 shares held by Venture Investors Early Stage II Limited Partnership; 170,400 shares held by Venture Investors Early Stage Fund III Limited Partnership. (6) Includes 774,312 shares owned by Schroder Ventures International Life Sciences Fund II LPI; 329,524 shares held by Schroder Ventures International Life Sciences Fund II LPII; 88,630 shares held by Schroder Ventures International Life Sciences Fund II LPIII; 22,282 shares held by Schroder Ventures International Life Sciences Fund Group Co-Investments Scheme; 11,842 shares held by Schroder Ventures International Life Sciences Fund II Strategic Partners LP; and 25,200 shares held by Schroder Ventures Investments Limited. Mr. Daniel is a manager of a company that provides consulting services to Schroder Ventures funds. Mr. Daniel disclaims beneficial ownership of the shares held by the 13 various Schroder Venture funds. The address of Schroder Ventures International Life Sciences Fund II, LPI, Schroder Ventures International Life Sciences Fund II LPII, and Schroder Ventures International Life Sciences Fund II LPIII is 875 Third Avenue, 22nd Floor, New York, NY 10022-6225. The address of Schroder Ventures Co-Investment Scheme is 22 Church Street, Hamilton HM 11, Bermuda. The address of Schroder Ventures Investments Limited is P.O. Box 255, Barfield House, St. Julian's Avenue, St. Peter Port, Guernsey GY1 4ND Channel Islands, United Kingdom. (7) Includes 1,020,863 shares held by the Burrill Agbio Capital Fund, LP. Mr. Burrill is general partner of Burrill Agbio Capital Fund, LP and disclaims beneficial ownership of these shares except to the extent of his pecuniary interest in these shares. (5) Includes 148,800 shares of common stock held in a voting trust for the benefit of Dr. Smith's family members. Peter Smith, Dr. Smith's brother, is the sole trustee of this voting trust. (6) Includes 1,196,550 shares held by Venture Investors of Wisconsin; 445,200 shares held by Venture Investors Early Stage II Limited Partnership; 170,400 shares held by Venture Investors Early Stage Fund III Limited Partnership. 16 SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE Section 16(a) of the Securities Exchange Act of 1934 requires our directors and executive officers, and any persons who beneficially own more than ten percent of our common stock, to file with the Securities and Exchange Commission initial reports of ownership and reports of changes in ownership of common stock. To our knowledge, based solely on review of the copies of such reports sent to us and written representations that no other reports were required, we believe that during the year ended December 31, 2002,2004, our directors, officers and ten percentten-percent shareholders complied with their Section 16(a) filing requirements, except thatas noted below. With respect to Maneesh Arora, Jacob Orville, and John Puisis, Form 4s, each for one transaction, were not timely filed; Form 4s for each transaction were subsequently filed. With respect to Lionel Sterling and Lander Brown, Form 3s were not timely filed and were subsequently filed. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS In 2000, the initial statementCompany entered into agreements with the University of beneficial ownershipWisconsin-Madison and the Wisconsin Alumni Research Foundation pursuant to which the Company provided enzyme and technical support for research projects by the University, and the Company received certain rights to inventions or other intellectual property arising out of the research project. The principal investigator for the projects was Dr. Eletr was filed late.Lloyd Smith, who is currently a director of the Company whose term as director will expire at the 2005 annual meeting of shareholders. 17 SHAREHOLDER RETURN PERFORMANCE GRAPH The following graph compares the percentage change in the cumulative return on our common stock against the NASDAQ Stock Market U.S. Index (the "NASDAQ Index") and a peer group composed of the companies listed below (the "Peer Group"). The graph assumes a $100 investment on February 9, 2001 (the date of our initial public offering) in each of our common stock, the NASDAQ Index and the Peer Group and assumes that all dividends, if paid, were reinvested. This table does not forecast future performance of our common stock. (PERFORMANCE GRAPH)
- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 2/9/01 3/31/01 6/30/01 9/30/01 12/31/01 3/31/02 6/30/02 9/30/02 12/31/02 3/31/03 - -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TWTI 100.00 63.64 93.91 57.45 66.82 30.45 20.36 12.27 24.45 29.82 - --------------------------------------------------------------------------------------------------------------------------- NASDAQ 100.00 74.48 87.44 60.66 78.93 74.68 59.22 47.43 54.05 54.28 - --------------------------------------------------------------------------------------------------------------------------- Peer Group 100.00 53.61 65.69 37.14 62.56 39.95 28.58 18.98 19.1786.60 132.47 91.84 112.48 118.85 105.97 91.23 111.79 102.42 - --------------------------------------------------------------------------------------------------------------------------- - --------------------- --------------------------------------------------------------------- 6/30/03 9/30/03 12/31/03 3/31/04 6/30/04 9/30/04 12/31/04 - --------------------- --------------------------------------------------------------------- TWTI 41.09 29.36 41.36 42.55 40.09 62.55 78.18 - ----------------------------------------------------------------------------------------------------- NASDAQ 65.67 72.32 81.08 80.71 82.87 76.76 88.04 - --------------------------------------------------------------------------------------------------------------- Peer Group 165.11 201.95 234.39 221.70 268.96 235.62 270.97 - -------------------------------------------------------------------------------------------------------------------------
14 The Peer Group consists of the following companies: Applera Corporation, Orchid Biosciences, Inc., Sequenom, Inc., Affymetrix, Inc. and Nanogen, Inc.Gen-Probe Incorporated, Celera Diagnostics, LLC, Ventana Medical Systems, Digene, Bio-Rad Laboratories. The foregoing graph and accompanying material shall not be "soliciting material" or to be "filed" with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under this Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent the Company specifically incorporates it by reference into such filing. OTHER MATTERS We know of no other matters to be submitted to the shareholders at the meeting. If any other matters properly come before the shareholders at the meeting, it is the intention of the persons named in the enclosed form of proxy to vote the shares they represent as the board of directors may recommend. By Order of the Board of Directors, /s/ LANCE FORS, PH.D. Lance Fors, Ph.D. Chairman of the Board and Chief Executive OfficerJOHN J. PUISIS John J. Puisis Dated: April 25, 2003 1529, 2005 18 THIRD WAVE TECHNOLOGIES, INC. THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS OF THIRD WAVE TECHNOLOGIES, INC. PROXY FOR ANNUAL MEETING OF SHAREHOLDERS IF NO CHOICE IS SPECIFIED, THE PROXY WILL BE VOTED "FOR" ITEMS 1THE DIRECTOR LISTED BELOW AND 2 BELOW. The undersigned shareholder of Third Wave Technologies, Inc., a Delaware corporation (the "Company"), hereby acknowledges receipt of the Proxy Statement of the Company dated April 25, 200329, 2005, and hereby appoints Lance ForsJames Herrmann and John Comerford, andKevin Conroy each of them proxies, and attorneys in fact, with full power to each of substitution, on behalf and in the name of the undersigned, to represent the undersigned at the Annual Meeting of Shareholders of the Company to be held at the offices of the Company at 9:00 a.m. on Tuesday, June 10, 200314, 2005, and any adjournment or adjournments thereof, and to vote all shares of common stock of the Company that the undersigned would be entitled to vote if the undersigned were present, as follows: 1. The electionElection of the following persons as directors of the Company to serve until their successors shall be duly elected and qualified:Director
NAME OF NOMINEE FOR AGAINSTWITHHELD - ------------------------- ------------------------- ----------------------------------------- --- -------- Gordon F. Brunner [ ] [ ] Sam H. Eletr [ ] [ ] John NeisLionel Sterling [ ] [ ]
For, except vote withheld from the following nominee(s): 2. To ratify the appointment of Ernst & Young LLP as independent auditorsregistered public accounting firm of the Company for the fiscal year ending December 31, 2003.2005. [ ] For [ ] Against [ ] Abstain 3. In their discretion, upon any such other matters which may properly come before the meeting or any adjournments thereof. The Board of Directors recommends a vote "FOR" each of the proposals. MARK FOR ADDRESS CHANGE AND NOTE AT LEFT [ ] Grant AuthorityMARK HERE IF YOU PLAN TO ATTEND THE MEETING [ ] Withhold Authority THIS PROXY WILL(PLEASE NOTE THAT MEMBERS OF MANAGEMENT ARE NOT EXPECTED TO BE VOTED IN ACCORDANCE WITHPHYSICALLY PRESENT AT THE SPECIFIC INDICATION ABOVE. IN THE ABSENCE OF SUCH INDICATION, THIS PROXY 20MEETING.) WILL BE VOTED FOR MANAGEMENT'S SLATE OF DIRECTORS AND FOR ALL OTHER ITEMS SET FORTH ABOVE AND, IN THE DISCRETION OF THE PROXYHOLDERS, ON ANY OTHER MATTERS WHICH MAY PROPERLY COME BEFORE THE MEETING OR ANY ADJOURNMENTS THEREOF. DATED: -------------------------, 2003 - -------------------------------- Signature of Shareholder - -------------------------------- PLEASE PRINT NAME(S) - -------------------------------- I plan to attend the meeting: [ ] Yes [ ] No Taxpayer Identification No. (or Social Security Number): ---------------------- Sign exactly as your name(s) appear(s) on the stock certificate(s). A corporation is requested to sign its name by its President or other authorized officer, with the office held designated. Executors, administrators, trustees, etc., are requested to so indicate when signing. If a stock is registered in two names, both should sign. SHAREHOLDERS SHOULD SIGN THIS PROXY PROMPTLY AND RETURN IT IN THE ENCLOSED ENVELOPE. PLEASE RETURN ALL PAGES OF THIS PROXYPROXY. Signature: Date: Signature: Date: -------------- ---------- -------------- ---------